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Genetic design automation: engineering fantasy or scientific renewal?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37060 45304 2012 7 PDF Available
Title
Genetic design automation: engineering fantasy or scientific renewal?
Abstract

The aim of synthetic biology is to make genetic systems more amenable to engineering, which has naturally led to the development of computer-aided design (CAD) tools. Experimentalists still primarily rely on project-specific ad hoc workflows instead of domain-specific tools, which suggests that CAD tools are lagging behind the front line of the field. Here, we discuss the scientific hurdles that have limited the productivity gains anticipated from existing tools. We argue that the real value of efforts to develop CAD tools is the formalization of genetic design rules that determine the complex relationships between genotype and phenotype.

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Genetic design automation: engineering fantasy or scientific renewal?
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 2, February 2012, Pages 120–126
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering