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Poly(glycoamidoamine)s: a broad class of carbohydrate-containing polycations for nucleic acid delivery

Paper ID Volume ID Publish Year Pages File Format Full-Text
37082 45309 2011 11 PDF Available
Title
Poly(glycoamidoamine)s: a broad class of carbohydrate-containing polycations for nucleic acid delivery
Abstract

In the era of nucleic acid therapeutics, there is an urgent need for non-viral delivery vehicles that can cross the extracellular and intracellular barriers and deliver nucleic acids to specific intracellular regions. This paper reviews the development of a subclass of polymer-based delivery vehicles termed poly(glycoamidoamine)s (PGAAs). The general design of this family consists of carbohydrate residues copolymerized with oligoethyleneamine units, which have proven to be an effective motif that promotes polyplex formation, efficient cellular internalization, high gene expression and low cytotoxicity with cultured cell lines and primary cell types. We then discuss the structure–property relationships of the PGAA class of delivery vehicles and studies aimed at understanding the mechanisms involved in cellular internalization and trafficking.

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Poly(glycoamidoamine)s: a broad class of carbohydrate-containing polycations for nucleic acid delivery
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 29, Issue 9, September 2011, Pages 443–453
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us