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The expanding scope of antimicrobial peptide structures and their modes of action

Paper ID Volume ID Publish Year Pages File Format Full-Text
37084 45309 2011 9 PDF Available
Title
The expanding scope of antimicrobial peptide structures and their modes of action
Abstract

Antimicrobial peptides (AMPs) are an integral part of the innate immune system that protect a host from invading pathogenic bacteria. To help overcome the problem of antimicrobial resistance, cationic AMPs are currently being considered as potential alternatives for antibiotics. Although extremely variable in length, amino acid composition and secondary structure, all peptides can adopt a distinct membrane-bound amphipathic conformation. Recent studies demonstrate that they achieve their antimicrobial activity by disrupting various key cellular processes. Some peptides can even use multiple mechanisms. Moreover, several intact proteins or protein fragments are now being shown to have inherent antimicrobial activity. A better understanding of the structure–activity relationships of AMPs is required to facilitate the rational design of novel antimicrobial agents.

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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 29, Issue 9, September 2011, Pages 464–472
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
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