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Systems biotechnology of animal cells: the road to prediction

Paper ID Volume ID Publish Year Pages File Format Full-Text
37090 45310 2012 9 PDF Available
Title
Systems biotechnology of animal cells: the road to prediction
Abstract

A central concern of biopharmaceutical R&D is the production of sufficient quantities of recombinant products from manufacturing processes based on animal cell culture. The way in which bioprocess researchers have addressed this question experienced a tremendous shift over the years, progressing from almost empirical to more rational approaches. A step further is the application of systems biotechnology: recent technological advances for large-scale cell state characterization and creative methods for host cell modeling are becoming crucial for next-generation bioprocess optimization. Here we provide an overview of the main trends towards this goal, with a focus on metabolic models as central scaffolds for data integration and prediction of bioprocess outcomes.

Keywords
systems biotechnology; mathematical modeling; computational prediction; animal cell culture; recombinant protein; bioprocess improvement
First Page Preview
Systems biotechnology of animal cells: the road to prediction
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 7, July 2012, Pages 377–385
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering