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β-Lactam and glycopeptide antibiotics: first and last line of defense?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37096 45311 2010 9 PDF Available
Title
β-Lactam and glycopeptide antibiotics: first and last line of defense?
Abstract

Most infections are caused by bacteria, many of which are ever-evolving and resistant to nearly all available antibiotics. β-Lactams and glycopeptides are used to combat these infections by inhibiting bacterial cell-wall synthesis. This mechanism remains an interesting target in the search for new antibiotics in light of failed genomic approaches and the limited input of major pharmaceutical companies. Several strategies have enriched the pipeline of bacterial cell-wall inhibitors; examples include combining screening strategies with lesser-explored microbial diversity, or reinventing known scaffolds based on structure-function relationships. Drugs developed using novel strategies will contribute to the arsenal in fight against the continued emergence of bacterial resistance.

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β-Lactam and glycopeptide antibiotics: first and last line of defense?
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 12, December 2010, Pages 596–604
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us