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Nanobody-based products as research and diagnostic tools

Paper ID Volume ID Publish Year Pages File Format Full-Text
37107 45312 2014 8 PDF Available
Title
Nanobody-based products as research and diagnostic tools
Abstract

•New production platforms for VHH and VHH-Fc antibodies were recently explored.•VHHs have distinct properties and often outperform conventional antibodies.•Several VHHs for protein purification and localisation are commercially available.

Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies, have received a progressively growing interest. As a result of the beneficial properties of these stable recombinant entities, they are currently highly valued proteins for multiple applications, including fundamental research, diagnostics, and therapeutics. Today, with the original patents expiring, even more academic and industrial groups are expected to explore innovative VHH applications. Here, we provide a thorough overview of novel implementations of VHHs as research and diagnostic tools, and of the recently evaluated production platforms for several VHHs and VHH-derived antibody formats.

Keywords
nanobody; recombinant protein production; antibody fragment; GFP-binding protein; plant production platform; yeast production platform
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 5, May 2014, Pages 263–270
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us