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Single-use disposable technologies for biopharmaceutical manufacturing

Paper ID Volume ID Publish Year Pages File Format Full-Text
37122 45313 2013 8 PDF Available
Title
Single-use disposable technologies for biopharmaceutical manufacturing
Abstract

The manufacture of protein biopharmaceuticals is conducted under current good manufacturing practice (cGMP) and involves multiple unit operations for upstream production and downstream purification. Until recently, production facilities relied on the use of relatively inflexible, hard-piped equipment including large stainless steel bioreactors and tanks to hold product intermediates and buffers. However, there is an increasing trend towards the adoption of single-use technologies across the manufacturing process. Technical advances have now made an end-to-end single-use manufacturing facility possible, but several aspects of single-use technology require further improvement and are continually evolving. This article provides a perspective on the current state-of-the-art in single-use technologies and highlights trends that will improve performance and increase the market penetration of disposable manufacturing in the future.

► Single-use disposable technologies in the manufacturing of biopharmaceuticals ► Advantages and limitations of single-use manufacturing ► Single-use systems for protein drug substance production process: key features, current scales and vendors ► Disposables reduce cost of clinical manufacturing and co-locating manufacturing.

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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 3, March 2013, Pages 147–154
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us