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From gene switches to mammalian designer cells: present and future prospects

Paper ID Volume ID Publish Year Pages File Format Full-Text
37123 45313 2013 14 PDF Available
Title
From gene switches to mammalian designer cells: present and future prospects
Abstract

Nature has evolved a treasury of biological molecules that are logically connected to networks, enabling cells to maintain their functional integrity. Similar to electronic circuits, cells operate as information-processing systems that dynamically integrate and respond to distinct input signals. Synthetic biology aims to standardize and expand the natural toolbox of biological building blocks to engineer novel synthetic networks in living systems. Mammalian cells harboring integrated designer circuits could work as living biocomputers that execute predictable metabolic and therapeutic functions. This review presents design principles of mammalian gene circuits, highlights recent developments, and discusses future challenges and prospects.

► Comprehensive overview of trigger-inducible transgene control switches. ► Construction of synthetic biology-inspired, multicomponent designer circuits. ► Future cell-based treatment strategies using prosthetic designer networks.

Keywords
synthetic biology; biocomputer; mammalian gene regulation; cell implants; gene circuits
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 3, March 2013, Pages 155–168
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us