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Extracellular matrix scaffolds for cartilage and bone regeneration

Paper ID Volume ID Publish Year Pages File Format Full-Text
37124 45313 2013 8 PDF Available
Title
Extracellular matrix scaffolds for cartilage and bone regeneration
Abstract

Regenerative medicine approaches based on decellularized extracellular matrix (ECM) scaffolds and tissues are rapidly expanding. The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration. Moreover, appropriately prepared ECM is biodegradable and does not elicit adverse immune responses. Successful clinical application of decellularized tissues has been reported in cardiovascular, gastrointestinal, and breast reconstructive surgery. At present, the use of ECM for osteochondral tissue engineering is attracting interest. Recent data underscore the great promise for future application of decellularized ECM for osteochondral repair. This review describes the rationale for using ECM-based approaches for different regenerative purposes and details the application of ECM for cartilage or osteochondral repair.

► Extracellular matrix scaffolds provide a bioactive platform for tissue regeneration. ► Osteochondral defect repair remains a great orthopedic and socioeconomic burden. ► We describe cartilage and bone decellularization and possible future directions. ► Extracellular matrix scaffolds hold great promise for osteochondral defect repair.

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Extracellular matrix scaffolds for cartilage and bone regeneration
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 3, March 2013, Pages 169–176
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us