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Combination approaches to combat multidrug-resistant bacteria

Paper ID Volume ID Publish Year Pages File Format Full-Text
37125 45313 2013 8 PDF Available
Title
Combination approaches to combat multidrug-resistant bacteria
Abstract

The increasing prevalence of infections caused by multidrug-resistant bacteria is a global health problem that has been exacerbated by the dearth of novel classes of antibiotics entering the clinic over the past 40 years. Herein, we describe recent developments toward combination therapies for the treatment of multidrug-resistant bacterial infections. These efforts include antibiotic–antibiotic combinations, and the development of adjuvants that either directly target resistance mechanisms such as the inhibition of β-lactamase enzymes, or indirectly target resistance by interfering with bacterial signaling pathways such as two-component systems (TCSs). We also discuss screening of libraries of previously approved drugs to identify nonobvious antimicrobial adjuvants.

► Combination approaches to combat multidrug-resistant bacteria. ► The problem of drug-resistant bacterial infections continues to worsen. ► Bacteria will inevitably acquire resistance against new antibiotics. ► Antibiotic–adjuvant combinations are an attractive approach to treat infections.

Keywords
antibiotic resistance; antibiotic adjuvant
First Page Preview
Combination approaches to combat multidrug-resistant bacteria
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 3, March 2013, Pages 177–184
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering