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Varying virulence: epigenetic control of expression noise and disease processes

Paper ID Volume ID Publish Year Pages File Format Full-Text
37135 45314 2011 9 PDF Available
Title
Varying virulence: epigenetic control of expression noise and disease processes
Abstract

Gene expression noise is a significant source of phenotypic heterogeneity in otherwise identical populations of cells. Phenotypic heterogeneity can cause reversible drug resistance in diseased cells, and thus a better understanding of its origins might improve treatment strategies. In eukaryotes, data strongly suggest that intrinsic noise arises from transcriptional bursts caused by slow, random transitions between inactive and active gene states that are mediated by chromatin remodeling. In this review, we consider how chromatin modifications might modulate gene expression noise and lead to phenotypic diversity in diseases as varied as viral infection and cancer. Additionally, we argue that this fundamental information can be applied to develop innovative therapies that counteract ‘pathogenic noise’ and sensitize all diseased cells to therapeutic intervention.

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Varying virulence: epigenetic control of expression noise and disease processes
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 29, Issue 10, October 2011, Pages 517–525
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering