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Chemically programmed antibodies

Paper ID Volume ID Publish Year Pages File Format Full-Text
37156 45317 2014 12 PDF Available
Title
Chemically programmed antibodies
Abstract

•cpAbs are a new class of pharmaceuticals.•Small molecules are equipped with the pharmacological properties of antibodies.•The small molecule serves as targeting moiety and the antibody serves as carrying moiety.•Several hundred patients have been treated with cpAbs in clinical trials.

Due to their unlimited chemical diversity, small molecules can rival monoclonal antibodies (mAbs) with respect to specificity and affinity for target molecules. However, key pharmacological properties of mAbs remain unmatched by small molecules. Chemical programming strategies have been developed for site-specific and covalent conjugation of small molecules to mAbs with unique reactivity centers. In addition to blending favorable features of small molecules and mAbs, chemically programmed antibodies (cpAbs) are economically attractive because they utilize the same mAb for an almost unlimited number of target molecule specificities, reducing manufacturing costs and shortening drug discovery and development time. Preclinical studies and clinical trials have begun to demonstrate the broad utility of cpAbs for the treatment and prevention of human diseases.

Keywords
pharmaceutical; monoclonal antibody; small molecule; site-specific conjugation; covalent conjugation
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Chemically programmed antibodies
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 4, April 2014, Pages 186–197
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us