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Immunotherapy applications of carbon nanotubes: from design to safe applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
37157 45317 2014 12 PDF Available
Title
Immunotherapy applications of carbon nanotubes: from design to safe applications
Abstract

•We summarize general functionalization strategies for the design of CNTs as an immunotherapeutic platform.•We examine the interaction of functionalized CNTs with different cells of the immune system.•Significant progress has been made in understanding the immunological implications of CNTs.•Potential applications of CNTs in immunotherapy need to factor in recent progress in immunotoxicology research.

Carbon nanotubes (CNTs) have the potential to overcome significant challenges related to vaccine development and immunotherapy. Central to these applications is an improved understanding of CNT interactions with the immune system. Unique properties such as high aspect ratio, flexible surface chemistry, and control over structure and morphology may allow for enhanced target specificity and transport of antigens across cell membranes. Although recent work has demonstrated the potential of CNTs to amplify the immune response as adjuvants, other results have also linked their proinflammatory properties to harmful health effects. Here, we review the recent advances of CNT-based immunological research, focusing on current understandings of therapeutic efficacy and mechanisms of immunotoxicology.

Keywords
carbon nanotubes; immunotherapy; immune system; cancer; toxicity; vaccine
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Immunotherapy applications of carbon nanotubes: from design to safe applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 4, April 2014, Pages 198–209
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us