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Science-based bioprocess design for filamentous fungi

Paper ID Volume ID Publish Year Pages File Format Full-Text
37176 45319 2013 8 PDF Available
Title
Science-based bioprocess design for filamentous fungi
Abstract

Industrial bioprocesses are commonly based on empiricism rather than scientific process understanding. In this review, we summarize current strategies for science-based bioprocess design and control for filamentous fungi aiming at reducing development times and increasing process economics. We discuss recent developments and trends regarding three crucial aspects throughout the bioprocess life cycle of filamentous fungi, namely (i) strain and inoculum characterization, (ii) morphology, and (iii) rheology, as well as their effects on process performance. Complex interconnections between strain, inoculum, morphology, rheology, and process design are outlined and discussed. Only combining different hard type sensors with soft sensor technology and the development of simplified mechanistic models can enable science-based bioprocess design for filamentous fungi.

► One-stop-encyclopedia for approaches to major obstacles in filamentous bioprocesses ► Review of links between strain, inoculum, morphology, rheology, and performance ► Outline for science-based bioprocess characterization, development, and control ► Systematic bioprocess design methods for optimized industrial biotechnology.

Keywords
bioprocess development; bioprocess characterization; filamentous fungi; strain screening; morphology; rheology
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 31, Issue 1, January 2013, Pages 37–44
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us