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Structural instability of plasmid biopharmaceuticals: challenges and implications

Paper ID Volume ID Publish Year Pages File Format Full-Text
37182 45320 2009 9 PDF Available
Title
Structural instability of plasmid biopharmaceuticals: challenges and implications
Abstract

The global increase in the number of applications involving therapeutic plasmid DNA (pDNA) is creating a need for large amounts of highly stable and purified molecules. One of the main obstacles during the developmental stages of a new therapeutic DNA molecule involves tackling a wide array of structural instability events occurring in/with pDNA and therefore assuring its structural integrity. This review focuses on major instability determinants in pDNA. Their elimination could be considered an important step towards the design of safer and more efficient plasmid molecules. Particular emphasis is given to mutations triggered by the presence of repeated sequences, instability events occurring during plasmid intracellular routing, instability mediated by insertion sequences and host genome integration.

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Structural instability of plasmid biopharmaceuticals: challenges and implications
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 9, September 2009, Pages 503–511
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us