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Roadmap for implementation of quality by design (QbD) for biotechnology products

Paper ID Volume ID Publish Year Pages File Format Full-Text
37187 45320 2009 8 PDF Available
Title
Roadmap for implementation of quality by design (QbD) for biotechnology products
Abstract

Quality by design (QbD) has been receiving a lot of attention in the pharmaceutical community of late. Successful QbD implementation requires a thorough understanding of the relationship between the critical quality attributes (CQAs) and the clinical properties of the product, the relationship between the process and CQAs and the variability in raw materials. This article presents a roadmap for successful QbD implementation for therapeutic biotechnology products. The approach presented here is aligned with existing regulatory guidance documents. Key developments are reviewed and case studies are used to illustrate these concepts. It is concluded that although several QbD concepts are being practiced by the biotechnology industry, successful dialogue and partnership between the industry and its regulators will be the key to successful QbD implementation.

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Roadmap for implementation of quality by design (QbD) for biotechnology products
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 9, September 2009, Pages 546–553
Authors
,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us