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Combating medical device fouling

Paper ID Volume ID Publish Year Pages File Format Full-Text
37201 45322 2014 7 PDF Available
Title
Combating medical device fouling
Abstract

•Biofouling as a result of thrombus and bacterial biofilms leads to device rejection.•Ideal devices treat the ailment, minimize adverse effects, and aid in regeneration.•Chemical and surface properties of device materials dictates the biological response.•Material design with passive and active approaches can be used to minimize biofouling.•Material integration with tissues and fluids will lead to device incorporation.

When interfaced with the biological environment, biomedical devices are prone to surface biofouling due to adhesion of microbial or thrombotic agents as a result of the foreign body response. Surface biofouling of medical devices occurs as a result of nonspecific adhesion of noxious substrates to the surface. Approaches for biofouling-resistant surfaces can be categorized as either the manipulation of surface chemical functionalities or through the incorporation of regulatory biomolecules. This review summarizes current strategies for creating biofouling-resistant surfaces based on surface hydrophilicity and charge, biomolecule functionalization, and drug elution. Reducing the foreign body response and restoring the function of cells around the device minimizes the risk of device rejection and potentially integrates devices with surrounding tissues and fluids. In addition, we discuss the use of peptides and NO as biomolecules that not only inhibit surface fouling, but also promote the integration of medical devices with the biological environment.

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Combating medical device fouling
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 3, March 2014, Pages 140–146
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us