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Computational tools for modeling xenometabolism of the human gut microbiota

Paper ID Volume ID Publish Year Pages File Format Full-Text
37203 45322 2014 9 PDF Available
Title
Computational tools for modeling xenometabolism of the human gut microbiota
Abstract

•We provide a conceptual overview of the hierarchy of xenometabolic processes in the gut microbiota.•We review computational tools relevant for modeling complex xenometabolic processes.•We present a unified perspective towards building holistic models of xenometabolism.

The gut microbiota is increasingly being recognized as a key site of metabolism for drugs and other xenobiotic compounds that are relevant to human health. The molecular complexity of the gut microbiota revealed by recent metagenomics studies has highlighted the need as well as the challenges for system-level modeling of xenobiotic metabolism in the gut. Here, we outline the possible pathways through which the gut microbiota can modify xenobiotics and review the available computational tools towards modeling complex xenometabolic processes. We put these diverse computational tools and relevant experimental findings into a unified perspective towards building holistic models of xenobiotic metabolism in the gut.

Keywords
metabolic modeling; microbial communities; functional metagenomics; biotransformation
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Computational tools for modeling xenometabolism of the human gut microbiota
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 32, Issue 3, March 2014, Pages 157–165
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us