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Towards the miniaturization of GPCR-based live-cell screening assays

Paper ID Volume ID Publish Year Pages File Format Full-Text
37207 45323 2012 9 PDF Available
Title
Towards the miniaturization of GPCR-based live-cell screening assays
Abstract

G protein-coupled receptors (GPCRs) play a key role in many physiological or disease-related processes and for this reason are favorite targets of the pharmaceutical industry. Although ∼30% of marketed drugs target GPCRs, their potential remains largely untapped. The discovery of new leads calls for the screening of thousands of compounds with high-throughput cell-based assays. Although microtiter plate-based high-throughput screening platforms are well established, microarray and microfluidic technologies hold potential for miniaturization, automation, and biosensor integration that may well redefine the format of GPCR screening assays. This paper reviews the latest research efforts directed to bringing microarray and microfluidic technologies into the realm of GPCR-based, live-cell screening assays.

Keywords
biosensors; drug discovery; G protein-coupled receptors; high-throughput screening; cell microarrays; microfluidics
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 11, November 2012, Pages 566–574
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us