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Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept

Paper ID Volume ID Publish Year Pages File Format Full-Text
37208 45323 2012 8 PDF Available
Title
Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept
Abstract

Recent advances in combinatorial protein engineering have made it possible to develop immunoglobulin (Ig)-based and non-Ig protein scaffolds that can potentially substitute for most whole antibody-associated properties and currently translate into biologicals with drug-like properties. During the past 10 years, the most validated scaffolds have reached the clinical development phase and, recently, one of them [Kalbitor® (Dyax)] has made it to the market, making these alternative scaffold proteins viable drug candidates in a post-antibody landscape. Interestingly, several scaffolds include an immune-active component as part of their therapeutic mode of action, which yielded spectacular clinical efficacy in some hematological malignancies. Here, we review the most recent clinical advances and analyze their benefits for patients.

Keywords
protein engineering; therapeutic antibody; clinical trial; drug development
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Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 11, November 2012, Pages 575–582
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us