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Relevance and challenges in modeling human gastric and small intestinal digestion

Paper ID Volume ID Publish Year Pages File Format Full-Text
37210 45323 2012 10 PDF Available
Title
Relevance and challenges in modeling human gastric and small intestinal digestion
Abstract

Gastric and small intestinal (GSI) models are increasingly used as an alternative to in vivo assays to answer many questions raised by industry and researchers. A broad range of in vitro systems is available, from static monocompartmental to dynamic multicompartmental models. However, these models require a compromise between technological complexity and biological significance. Further efforts and technological innovations are still needed to improve in vitro models and meet growing demands in the areas of nutrition and health. This review describes the models available to date for the human stomach and small intestine and highlights their relevance in nutritional, toxicological, pharmaceutical, and microbiological studies. Limitations and challenges facing artificial digestion technology are also discussed.

Keywords
human digestion; stomach and small intestine; in vitro models
First Page Preview
Relevance and challenges in modeling human gastric and small intestinal digestion
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 11, November 2012, Pages 591–600
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering