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Essential genes as antimicrobial targets and cornerstones of synthetic biology

Paper ID Volume ID Publish Year Pages File Format Full-Text
37211 45323 2012 7 PDF Available
Title
Essential genes as antimicrobial targets and cornerstones of synthetic biology
Abstract

Essential genes are absolutely required for the survival of any living entity. Investigation of essential genes is therefore expected to advance tremendously our understanding of the universal principles of life. Determination of a minimal set of essential genes needed to sustain life also plays an important role in the emerging field of synthetic biology, whose goals include creation of a stringently controlled minimal cell with predesigned phenotypic traits. In addition, due to their indispensability for survival of bacteria, genes encoding essential cellular functions have great potential in medicine as promising targets for the development of novel antimicrobials. Here, we review recent advances in the investigation of essential genes, with emphasis on the practical applications in medicine and synthetic biology.

Keywords
essential gene; synthetic biology; antimicrobial target; minimal genome
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 11, November 2012, Pages 601–607
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us