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Structure-based antigen design: a strategy for next generation vaccines

Paper ID Volume ID Publish Year Pages File Format Full-Text
37230 45326 2008 9 PDF Available
Title
Structure-based antigen design: a strategy for next generation vaccines
Abstract

Vaccine design is progressing from empiricism towards the increasingly rational presentation of the targets of protective immunity. Nevertheless, most current vaccine antigens are essentially the native macromolecules of pathogens. These molecules are adapted to evade, not induce, immunity. High resolution structures reveal the electrostatic surfaces recognized by neutralizing antibodies and the architectures underlying these surfaces, thereby identifying which substructures must be left intact and which can be changed to optimize biochemical and immunologic performance. Armed with detailed structural information, we can engineer optimized antigens that are more stable, homogeneous, and efficiently produced, making immunization more practical and affordable. Understanding the structural basis for immunogenicity and immunodominance will allow us to improve vaccine efficacy and broaden the range of vaccine-preventable diseases.

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Structure-based antigen design: a strategy for next generation vaccines
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 26, Issue 12, December 2008, Pages 659–667
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering