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Rational and systematic protein purification process development: the next generation

Paper ID Volume ID Publish Year Pages File Format Full-Text
37253 45329 2009 7 PDF Available
Title
Rational and systematic protein purification process development: the next generation
Abstract

Current biopharmaceutical manufacturing strongly relies on using purification platform processes, offering harmonization of practices and speed-to-market. However, the ability of such processes to respond quickly to anticipated higher quality and capacity demands is under question. Here, we describe novel approaches for purification process development that incorporate biothermodynamics, modern high throughput experimentation and simulation tools. Such development leads to production platform-specific databases containing thermodynamic protein descriptors of major host cell proteins over a range of experimental conditions. This will pave the way for in silico purification process development, providing better process understanding and the potential to respond quickly to product quality and market demands. Future efforts will focus on improving this field further and enabling more rationale in process development.

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Rational and systematic protein purification process development: the next generation
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 12, December 2009, Pages 673–679
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us