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Application of systems biology for bioprocess development

Paper ID Volume ID Publish Year Pages File Format Full-Text
37260 45330 2008 9 PDF Available
Title
Application of systems biology for bioprocess development
Abstract

Random mutagenesis or genetic modification of an organism without consideration of its consequences to the entire system might cause unwanted changes in cellular metabolism. Systems metabolic engineering thus aims to develop strains by performing metabolic engineering within a systems biology framework, in which entire cellular networks are optimized and fermentation and downstream processes are considered at early stages. Thus, regulatory, metabolic and other cellular networks are engineered in an integrated manner. Here, we review the applications of systems biology for the development of strains and bioprocesses by means of several successful examples and, furthermore, discuss future prospects.

First Page Preview
Application of systems biology for bioprocess development
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 26, Issue 8, August 2008, Pages 404–412
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering