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Genome-wide approaches to systematically identify substrates of the ubiquitin–proteasome pathway

Paper ID Volume ID Publish Year Pages File Format Full-Text
37271 45331 2010 7 PDF Available
Title
Genome-wide approaches to systematically identify substrates of the ubiquitin–proteasome pathway
Abstract

The ubiquitin–proteasome system handles the majority of controlled proteolysis in eukaryotes. Defects in the ubiquitin–proteasome system have been implicated in diseases ranging from cancers to neurodegenerative disorders. However, the precise role of ubiquitin–proteasome-mediated degradation in health and disease is far from clear. A major challenge is to link specific substrates directly to a particular degradation pathway. Here, we review genome-wide approaches that have been developed in recent years to comprehensively identify ubiquitylated substrates of a particular pathway. Components of the ubiquitin–proteasome system are attractive drug targets, as illustrated by the efficacy of some proteasome inhibitors in the treatment of multiple myeloma. Information that has emerged from these studies could reveal novel drug targets and strategies for treating human diseases.

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Genome-wide approaches to systematically identify substrates of the ubiquitin–proteasome pathway
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 9, September 2010, Pages 461–467
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us