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Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways

Paper ID Volume ID Publish Year Pages File Format Full-Text
37273 45331 2010 9 PDF Available
Title
Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways
Abstract

Cultured mammalian cells are major vehicles for producing therapeutic proteins, and energy metabolism in those cells profoundly affects process productivity. The characteristic high glucose consumption and lactate production of industrial cell lines as well as their adverse effects on productivity have been the target of both cell line and process improvement for several decades. Recent research advances have shed new light on regulation of glucose metabolism and its links to cell proliferation. This review highlights our current understanding in this area of crucial importance in bioprocessing and further discusses strategies for harnessing new findings toward process enhancement through the manipulation of cellular energy metabolism.

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Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 9, September 2010, Pages 476–484
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us