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The complexity of cellular dedifferentiation: implications for regenerative medicine

Paper ID Volume ID Publish Year Pages File Format Full-Text
37276 45333 2009 4 PDF Available
Title
The complexity of cellular dedifferentiation: implications for regenerative medicine
Abstract

Cellular dedifferentiation underlies topical issues in biology, such as regeneration and somatic cell nuclear transfer (SCNT), and signifies the withdrawal of cells from a given differentiated state into a ‘stem cell’-like state that confers pluripotency. Recently, there has been growing interest in exploiting the dedifferentiation process to obtain autologous stem cell lineages for use in regenerative medicine. This approach holds great promise, particularly in view of the ethical concerns invoked over the use of human embryonic stem cells in research and the problem of transplant rejection. However, new insights provided by the study of this process in plants and animals have highlighted the complexity and hazards of cellular dedifferentiation.

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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 6, June 2009, Pages 329–332
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us