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Perspectives on cell reprogramming with RNA

Paper ID Volume ID Publish Year Pages File Format Full-Text
37285 45334 2012 7 PDF Available
Title
Perspectives on cell reprogramming with RNA
Abstract

Recent advances in cell reprogramming have permitted the development of different stem cell lines and specific differentiated cell types using distinct technologies. Cell reprogramming is largely mediated by DNA and RNA. In this review, we explore the RNA-mediated cell reprogramming to induce specific target cell generation including stem cells, brain cells and cardiac cells. The ability of RNA populations to produce direct cell to cell phenotypic conversion is called Transcriptome Induced PhenotypeRemodeling (TIPeR). The theory and utility of RNA use for cellular reprogramming is explored in this review.

Keywords
RNA-mediated; transdifferentiation; TIPeR; transcriptome transfer; RNA; cellular reprogramming
First Page Preview
Perspectives on cell reprogramming with RNA
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 5, May 2012, Pages 243–249
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering