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Detecting RNA viruses in living mammalian cells by fluorescence microscopy

Paper ID Volume ID Publish Year Pages File Format Full-Text
37308 45338 2011 7 PDF Available
Title
Detecting RNA viruses in living mammalian cells by fluorescence microscopy
Abstract

Traditional methods that rely on viral isolation and culture techniques continue to be the gold standards used for detection of infectious viral particles. However, new techniques that rely on visualization of live cells can shed light on understanding virus–host interaction for early stage detection and potential drug discovery. Live-cell imaging techniques that incorporate fluorescent probes into viral components provide opportunities for understanding mRNA expression, interaction, and virus movement and localization. Other viral replication events inside a host cell can be exploited for non-invasive detection, such as single-virus tracking, which does not inhibit viral infectivity or cellular function. This review highlights some of the recent advances made using these novel approaches for visualization of viral entry and replication in live cells.

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Detecting RNA viruses in living mammalian cells by fluorescence microscopy
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 29, Issue 7, July 2011, Pages 307–313
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us