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Engineering strategies to emulate the stem cell niche

Paper ID Volume ID Publish Year Pages File Format Full-Text
37316 45339 2010 8 PDF Available
Title
Engineering strategies to emulate the stem cell niche
Abstract

The stem cell niche is an anatomical site that contains a reservoir of multipotent stem cells (SCs) that can maintain normal tissue, or replenish injured or aged cell populations, in response to mechanisms that regulate whether they should remain quiescent, undergo self-renewal, or differentiate. The choice among these hallmark SC behaviors is governed by intricate soluble and “solid phase” signals that are systemic or presented by the local niche cells. In this review, we discuss the progress achieved in understanding the mechanisms and principles that govern microenvironmental regulation of SC behavior, and focus on novel approaches that have been developed to synthesize this basic information to engineer creative strategies for harnessing and controlling SCs ex vivo and in vivo.

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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 3, March 2010, Pages 117–124
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us