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Ultraslow microdialysis and microfiltration for in-line, on-line and off-line monitoring

Paper ID Volume ID Publish Year Pages File Format Full-Text
37320 45339 2010 9 PDF Available
Title
Ultraslow microdialysis and microfiltration for in-line, on-line and off-line monitoring
Abstract

In medicine and biotechnology, close monitoring of molecular processes might assist to optimise therapeutic interventions and production of biochemicals, respectively. Here, we summarize the current status of two automatic and continuous sampling technologies, microdialysis and microfiltration, which facilitate both in vivo and in vitro monitoring of nearly any analyte, because they can be combined easily with many analytical techniques. Conventional microdialysis and microfiltration, which require collecting relatively large samples, are however often impractical and semi-quantitative; hence, we focus on ultraslow sampling to circumvent such limitations. Ultraslow microdialysis and microfiltration already have been used successfully for quantitative pharmacokinetics, glucose metabolism (e.g. of the brain), cytokines and proteomics (e.g. tumour secretomes), both in vivo and in vitro.

First Page Preview
Ultraslow microdialysis and microfiltration for in-line, on-line and off-line monitoring
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 3, March 2010, Pages 150–158
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering