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Lentiviral vectors with measles virus glycoproteins – dream team for gene transfer?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37332 45341 2009 7 PDF Available
Title
Lentiviral vectors with measles virus glycoproteins – dream team for gene transfer?
Abstract

Lentiviral vectors are potent gene transfer vehicles frequently applied in research and lately also in clinical applications. Recent improvements have come from combining lentiviral vectors with engineered envelope proteins, which now allow targeting of cell entry to any cell population of interest, as well as the transduction of quiescent cells of the haematopoietic system. We propose that measles virus envelope glycoproteins are especially well suited for this purpose because they can mediate pH-independent cell entry at the cell surface membrane and can induce cytoskeleton rearrangements that facilitate the transport of lentiviral core particles to the cell nucleus. Lentiviral vectors pseudotyped with measles virus glycoproteins are expected to improve the safety and efficacy of gene transfer to human cells.

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Lentiviral vectors with measles virus glycoproteins – dream team for gene transfer?
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 5, May 2009, Pages 259–265
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us