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Inhibiting host–pathogen interactions using membrane-based nanostructures

Paper ID Volume ID Publish Year Pages File Format Full-Text
37343 45342 2012 8 PDF Available
Title
Inhibiting host–pathogen interactions using membrane-based nanostructures
Abstract

Virulent strains of bacteria and viruses recognize host cells by their plasma membrane receptors and often exploit the native translocation machinery to invade the cell. A promising therapeutic concept for early interruption of pathogen infection is to subvert this pathogenic trickery using exogenously introduced decoys that present high-affinity mimics of cellular receptors. This review highlights emerging applications of molecularly engineered lipid-bilayer-based nanostructures, namely (i) functionalized liposomes, (ii) supported colloidal bilayers or protocells and (iii) reconstituted lipoproteins, which display functional cellular receptors in optimized conformational and aggregative states. These decoys outcompete host cell receptors by preferentially binding to and neutralizing virulence factors of both bacteria and viruses, thereby promising a new approach to antipathogenic therapy.

Keywords
host–pathogen interaction; antiviral; antipathogenic decoys; membrane receptors; binding affinity; reconstituted (synthetic) lipoprotein; membrane nanostructures
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 6, June 2012, Pages 323–330
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us