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Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D

Paper ID Volume ID Publish Year Pages File Format Full-Text
37344 45342 2012 11 PDF Available
Title
Novel advances in the design of three-dimensional bio-scaffolds to control cell fate: translation from 2D to 3D
Abstract

Recreating the most critical aspects of the native extracellular matrix (ECM) is fundamental to understand and control the processes regulating cell fate and cell function. From the ill-defined complexity to the controlled simplicity, we discuss the different strategies that are being carried out by scientists worldwide to achieve the latest advances in the sophistication of three-dimensional (3D) scaffolds, stressing their impact on cell biology, tissue engineering and regenerative medicine. Synthetic and naturally derived polymers like polyethylene glycol, alginate, agarose, etc., together with micro- and nanofabrication techniques are allowing the creation of 3D models where biophysical and biochemical variables can be modified with high precision, orthogonality and even in real-time.

Keywords
biomaterial; 3D scaffolds; cell encapsulation; artificial ECM; tissue engineering; regenerative medicine
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 6, June 2012, Pages 331–341
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us