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Distributed computation: the new wave of synthetic biology devices

Paper ID Volume ID Publish Year Pages File Format Full-Text
37345 45342 2012 8 PDF Available
Title
Distributed computation: the new wave of synthetic biology devices
Abstract

Synthetic biology (SB) offers a unique opportunity for designing complex molecular circuits able to perform predefined functions. But the goal of achieving a flexible toolbox of reusable molecular components has been shown to be limited due to circuit unpredictability, incompatible parts or random fluctuations. Many of these problems arise from the challenges posed by engineering the molecular circuitry: multiple wires are usually difficult to implement reliably within one cell and the resulting systems cannot be reused in other modules. These problems are solved by means of a nonstandard approach to single cell devices, using cell consortia and allowing the output signal to be distributed among different cell types, which can be combined in multiple, reusable and scalable ways.

Keywords
synthetic biology; distributed computation; molecular circuit.
First Page Preview
Distributed computation: the new wave of synthetic biology devices
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 30, Issue 6, June 2012, Pages 342–349
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering