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Does a targeting ligand influence nanoparticle tumor localization or uptake?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37352 45343 2008 7 PDF Available
Title
Does a targeting ligand influence nanoparticle tumor localization or uptake?
Abstract

Inclusion of a tumor-targeting molecule in nanosized delivery systems increases their in vivo efficacy. However, the biodistribution and pharmacokinetics of the uptake of such particles have not yet been well addressed. Several recent papers have suggested that tumor-targeting ligands function primarily to increase intracellular uptake of the nanocomplex and do not influence tumor localization. However, other reports indicate that they do play a role in the accumulation in the tumor. One difference might be the presence or absence of poly-[ethylene glycol] (PEG) in the complex and its impact on the enhanced permeability and retention (EPR) effect. Further studies are clearly needed to more fully elucidate the influence of composition on tumor-targeted, systemic delivery of nanoparticles.

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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 26, Issue 10, October 2008, Pages 552–558
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
Price after discount Only $4.95
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Any Questions? feel free to contact us