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Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development

Paper ID Volume ID Publish Year Pages File Format Full-Text
37388 45348 2010 9 PDF Available
Title
Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development
Abstract

The future of industrial biotechnology requires efficient development of highly productive and robust strains of microorganisms. Present praxis of strain development cannot adequately fulfill this requirement, primarily owing to the inability to control reactions precisely at a molecular level, or to predict reliably the behavior of cells upon perturbation. Recent developments in two areas of biology are changing the situation rapidly: structural biology has revealed details about enzymes and associated bioreactions at an atomic level; and synthetic biology has provided tools to design and assemble precisely controllable modules for re-programming cellular metabolic circuitry. However, because of different emphases, to date, these two areas have developed separately. A linkage between them is desirable to harness their concerted potential. We therefore propose structural synthetic biotechnology as a new field in biotechnology, specifically for application to the development of industrial microbial strains.

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Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 10, October 2010, Pages 534–542
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
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Online Support
Any Questions? feel free to contact us