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Computational fluid dynamics for improved bioreactor design and 3D culture

Paper ID Volume ID Publish Year Pages File Format Full-Text
37415 45353 2008 7 PDF Available
Title
Computational fluid dynamics for improved bioreactor design and 3D culture
Abstract

The complex relationship between the hydrodynamic environment and surrounding tissues directly impacts on the design and production of clinically useful grafts and implants. Tissue engineers have generally seen bioreactors as ‘black boxes’ within which tissue engineering constructs (TECs) are cultured. It is accepted that a more detailed description of fluid mechanics and nutrient transport within process equipment can be achieved by using computational fluid dynamics (CFD) technology. This review discusses applications of CFD for tissue engineering-related bioreactors – fluid flow processes have direct implications on cellular responses such as attachment, migration and proliferation. We conclude that CFD should be seen as an invaluable tool for analyzing and visualizing the impact of fluidic forces and stresses on cells and TECs.

First Page Preview
Computational fluid dynamics for improved bioreactor design and 3D culture
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 26, Issue 4, April 2008, Pages 166–172
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering