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Catalytic effectiveness, a measure of enzyme proficiency for industrial applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
37425 45354 2009 4 PDF Available
Title
Catalytic effectiveness, a measure of enzyme proficiency for industrial applications
Abstract

Recent attention has been paid to the inadequacy of using the ratio Vmax/KM as a measure of enzyme performance, particularly in the context of industrial biocatalysis. This can lead to misleading expectations of enzyme performance and can be troublesome when used to select among different variants for scale-up evaluation under process conditions. To address these issues, we derive the average velocity based on the time-integrated behavior of the enzyme over the course of the reaction. The resulting expression, deemed catalytic effectiveness, captures important features of the system that have heretofore been ignored (such as highly variable substrate and/or product concentrations and inhibition) and offers a rigorous way to compare enzymes for their capacity to carry out industrial transformations.

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Catalytic effectiveness, a measure of enzyme proficiency for industrial applications
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 3, March 2009, Pages 137–140
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering