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Purpose-driven biomaterials research in liver-tissue engineering

Paper ID Volume ID Publish Year Pages File Format Full-Text
37450 45357 2011 9 PDF Available
Title
Purpose-driven biomaterials research in liver-tissue engineering
Abstract

Bottom-up engineering of microscale tissue (“microtissue”) constructs to recapitulate partially the complex structure–function relationships of liver parenchyma has been realized through the development of sophisticated biomaterial scaffolds, liver-cell sources, and in vitro culture techniques. With regard to in vivo applications, the long-lived stem/progenitor cell constructs can improve cell engraftment, whereas the short-lived, but highly functional hepatocyte constructs stimulate host liver regeneration. With regard to in vitro applications, microtissue constructs are being adapted or custom-engineered into cell-based assays for testing acute, chronic and idiosyncratic toxicities of drugs or pathogens. Systems-level methods and computational models that represent quantitative relationships between biomaterial scaffolds, cells and microtissue constructs will further enable their rational design for optimal integration into specific biomedical applications.

First Page Preview
Purpose-driven biomaterials research in liver-tissue engineering
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 29, Issue 3, March 2011, Pages 110–118
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering