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Substrate-mediated nucleic acid delivery from self-assembled monolayers

Paper ID Volume ID Publish Year Pages File Format Full-Text
37451 45357 2011 8 PDF Available
Title
Substrate-mediated nucleic acid delivery from self-assembled monolayers
Abstract

Substrate-mediated nucleic acid (NA) delivery involves the immobilization of NAs or NA delivery vehicles to biomaterials for localized transfection of cells. Self-assembled monolayers (SAMs) offer an easy system to immobilize delivery vectors. SAMs form well-defined surfaces; therefore, the effect of surface composition on vector immobilization and transfection efficiency can also be studied. To date, the most effective SAM-mediated delivery systems have utilized nonspecific interactions for immobilization; however, systems that rely on specific interactions between vector and surface can impart higher control of spatial and/or temporal delivery. This review summarizes systems that use both specific and nonspecific interactions for gene delivery from SAMs; highlights progress and remaining challenges; and explores other specific recognition modalities that might be employed for future applications in surface-mediated NA delivery.

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Substrate-mediated nucleic acid delivery from self-assembled monolayers
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 29, Issue 3, March 2011, Pages 119–126
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us