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Inter-individual variation in expression: a missing link in biomarker biology?

Paper ID Volume ID Publish Year Pages File Format Full-Text
37468 45359 2009 6 PDF Available
Title
Inter-individual variation in expression: a missing link in biomarker biology?
Abstract

The past decade has seen an explosion of variation data demonstrating that diversity of both protein-coding sequences and of regulatory elements of protein-coding genes is common and of functional importance. In this article, we argue that genetic diversity can no longer be ignored in studies of human biology, even research projects without explicit genetic experimental design, and that this knowledge can, and must, inform research. By way of illustration, we focus on the potential role of genetic data in case–control studies to identify and validate cancer protein biomarkers. We argue that a consideration of genetics, in conjunction with proteomic biomarker discovery projects, should improve the proportion of biomarkers that can accurately classify patients.

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Inter-individual variation in expression: a missing link in biomarker biology?
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 1, January 2009, Pages 5–10
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us