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Cytotoxicity and immunostimulation: double attack on cancer cells with polymeric therapeutics

Paper ID Volume ID Publish Year Pages File Format Full-Text
37469 45359 2009 7 PDF Available
Title
Cytotoxicity and immunostimulation: double attack on cancer cells with polymeric therapeutics
Abstract

The successful treatment of cancer with conventional drugs is frequently complicated by the resistance of tumor cells to such a non-specific therapy. Over the last few years, immunotherapy has gained attention as a tumor-specific approach. Recent findings demonstrated that some conventional cytostatics stimulate local anticancer responses. New anticancer drugs, including their polymeric derivatives, are currently being developed with the aim of destroying tumors more effectively and more specifically. Among these, the water-soluble conjugates of doxorubicin with N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer carrier have emerged as efficient therapeutics because they are able to not only directly destroy cancer cells but also elicit systemic tumor-specific anticancer responses. Here, we discuss new insights into their mechanisms of immune surveillance, which could suggest novel approaches to cancer therapy.

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Cytotoxicity and immunostimulation: double attack on cancer cells with polymeric therapeutics
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 27, Issue 1, January 2009, Pages 11–17
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us