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The urokinase plasminogen activator receptor as a gene therapy target for cancer

Paper ID Volume ID Publish Year Pages File Format Full-Text
37491 45361 2007 7 PDF Available
Title
The urokinase plasminogen activator receptor as a gene therapy target for cancer
Abstract

Urokinase plasminogen activator (uPA) and/or its receptor (uPAR) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. Impairment of uPA and/or uPAR function, or inhibition of the expression of these components, impedes the metastatic potential of many tumours. Several approaches have been employed to target uPAR with the aim of disrupting its ligand-independent action or interaction with uPA, including the more recent antigene technology. This review discusses the in vivo use of antigene approaches for downregulating uPAR as a potential therapy for cancer. Preclinical studies are advancing towards the translational phase, provided that established orthotopic tumours, which mimic clinical progression and presentation, are treated using clinically acceptable modes of nucleic acid delivery.

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The urokinase plasminogen activator receptor as a gene therapy target for cancer
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 25, Issue 1, January 2007, Pages 33–39
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us