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RNAi and small interfering RNAs in human disease therapeutic applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
37498 45362 2010 10 PDF Available
Title
RNAi and small interfering RNAs in human disease therapeutic applications
Abstract

Small interfering RNAs (siRNAs) have been shown to effectively downregulate gene expression in human cells, giving them potential to eradicate disease. Prospects for clinical applications are discussed in this review, along with an overview of recent history and our current understanding of siRNAs used for therapeutic application in human diseases, such as cancer and viral infections. Over recent years, progress has been made in lipids, ligands, nanoparticles, polymers and viral vectors as delivery agents and for gene-based expression of siRNA to enhance the efficacy and specificity of these methods while at the same time reducing toxicity. It has become apparent that given the recent advances in chemistry and delivery, RNAi will soon prove to be an important and widely used therapeutic modality.

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RNAi and small interfering RNAs in human disease therapeutic applications
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 11, November 2010, Pages 570–579
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us