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Meta-analysis for microarray studies of the genetics of complex traits

Paper ID Volume ID Publish Year Pages File Format Full-Text
37510 45364 2007 3 PDF Available
Title
Meta-analysis for microarray studies of the genetics of complex traits
Abstract

In comparison to other complex disease traits, alcoholism and alcohol abuse are influenced by the combined effects of many genes that alter susceptibility, phenotypic expression and associated morbidity, respectively. Many genetic studies, in both animal models and humans, have identified genetic intervals containing genes that influence alcoholism or behavioral responses to ethanol. Concurrently, a growing number of microarray studies have identified gene expression differences related to ethanol drinking or other ethanol behaviors. However, concerns about the statistical power of these experiments, combined with the complexity of the underlying phenotypes, have greatly hampered the identification of candidate genes underlying ethanol behaviors. Meta-analysis approaches using recent compilations of large datasets of microarray, behavioral and genetic data promise improved statistical power for detecting the genes or gene networks affecting ethanol behaviors and other complex traits.

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Meta-analysis for microarray studies of the genetics of complex traits
Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 25, Issue 2, February 2007, Pages 45–47
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering