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New enzymes for biotransformations: microbial alkyl sulfatases displaying stereo- and enantioselectivity

Paper ID Volume ID Publish Year Pages File Format Full-Text
37516 45364 2007 6 PDF Available
Title
New enzymes for biotransformations: microbial alkyl sulfatases displaying stereo- and enantioselectivity
Abstract

The majority of hydrolytic enzymes used in white biotechnology for the production of non-natural compounds – such as carboxyl ester hydrolases, lipases and proteases – show a certain preference for a given enantiomer. However, they are unable to alter the stereochemistry of the substrate during catalysis with respect to inversion or retention of configuration. The latter can be achieved by (alkyl) sulfatases, which can be employed for the enantio-convergent transformation of racemic sulfate esters into a single stereoisomeric secondary alcohol, with a theoretical yield of 100%. This is a major improvement over traditional kinetic resolution processes, which yield both enantiomers, each at 50%.

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New enzymes for biotransformations: microbial alkyl sulfatases displaying stereo- and enantioselectivity
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 25, Issue 2, February 2007, Pages 83–88
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us