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Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production

Paper ID Volume ID Publish Year Pages File Format Full-Text
37521 45365 2010 8 PDF Available
Title
Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production
Abstract

New, highly sensitive, biosensor concepts make it possible to assay biomacromolecules at concentrations that previously were far below the limit of detection. The previous generation of assays used in quality control situations during biotechnological production was designed primarily for monitoring target molecules, which typically appeared in high concentrations. Hence, novel analytical techniques with high sensitivity should become increasingly important in meeting the demands from regulatory agencies with regard to declaring levels of impurities in biopharmaceuticals. Such techniques also open up opportunities for a range of other challenging measurements, for example, in the area of biohazards. This review describes the development of immuno-based biosensors and exemplifies these by presenting analyses of common impurities in biopharmaceutical production.

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Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 1, January 2010, Pages 20–27
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us