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Liposomal gene delivery mediated by tissue-engineered scaffolds

Paper ID Volume ID Publish Year Pages File Format Full-Text
37522 45365 2010 9 PDF Available
Title
Liposomal gene delivery mediated by tissue-engineered scaffolds
Abstract

In the absence of any ideal gene delivery carrier despite the recent explosion of novel carrier systems, the current trend is to explore the complementary synergy promised by a combination of delivery systems such as liposomes, which are the most widely researched versatile non-viral carriers, and tissue-engineered scaffolds with macrostructures of defined architecture comprised of natural or synthetic macromolecules. Here, we discuss the recent advances in liposomal gene delivery and the possible benefits of a combined liposome–scaffold approach, such as long-term expression, enhanced stability, reduction in toxicity and ability to produce spatio-temporal expression patterns. This approach is generating significant impact in the field as a result of its potential for extended localised gene delivery for applications in a variety of clinical conditions.

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Liposomal gene delivery mediated by tissue-engineered scaffolds
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Publisher
Database: Elsevier - ScienceDirect
Journal: - Volume 28, Issue 1, January 2010, Pages 28–36
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us